压电石英晶体生物传感器及其应用研究进展

Advances in Piezoelectric Quartz Crystal Biosensor and Its Applications

压电石英晶体生物传感器是利用压电石英晶体振荡频率对晶体表面质量负载和表面性状如密度、粘度、电导、介电常数等的高度敏感性与生物识别分子的高度特异性相结合发展起来的一种新型传感器。它具有灵敏度高、特异性好 ;操作简单 ,不需任何标记 ;检测速度快 ,成本低廉 ;仪器体积小 ,重量轻 ,能实时检测等特点。特别适用于临床实验诊断、环境监测、食品卫生检验、工业生产实时监测等野外流动作业和在线检测。本文就压电石英晶体生物传感器的原理、基本结构、特点及其应用等方面进行综述。

Piezoelectric quartz crystal biosensor is a new sensor developed with the comprehensive utilization of the high sensitivity to mass and the surface characteristics of quartz crystal such as density, viscosity, dielectric constant, conductance, and the high specificity of biologic identification molecules. It has the features of high sensitivity , high specificity, simple operation, high analysis speed, low cost, small size, on line detection, etc. It can be of wide application in the areas of medical laboratory diagnosis, environment monitor, foods sanitary control and industrial production. In this paper, the fundamental principle, structure and its applications are reviewed.