细胞黏附基础与肌腱组织工程

Basic Researches on Cell Adhesion and Its Application in Tendon Tissue Engineering

细胞黏附是组织工程学中一个基础而非常重要的问题 ,纤连蛋白和整合素受体是细胞黏附中最重要的结构 ,同时成纤维细胞还通过表面受体直接与基质中的 I型胶原结合 ,另外成纤维细胞也可通过表面受体与纤层蛋白结合等而使细胞黏附。本文综合了近几年来国外的有关文献 ,详细阐述了纤连蛋白和整合素的结构及功能。介绍肌腱组织中与细胞黏附有关的结构。提出组织工程学产品保存过程中细胞与细胞外基质间黏附力的影响尚无文献报道 ,研究细胞与细胞外基质之间的黏附 ,寻找对其不影响或影响很小的保存方法是我们需要解决的一个重要课题。

Cell adhesion is a basic and very important tissue in the field of tissue engineering. Fibronectin and integrins are the most important elements to cell adhesioin. Some surface receptors of fibroblast can also conjugate with type I collagen in extracellular matrix (ECM) directly. Laminin receptors on the surface of fibroblast bound to laminin also play a role in cell adhesion. In this paper are reviewed a number of related articles. The structures and function of fibronectin and integrins are discussed in detail; the tendon cell's adhesion structures are also discussed. Yet, there was scarcely any paper on the effects which the preservation of tissue engineered prodncts may have on cells' adhesion fo ECM. Therefore, researching on cell adhesion and finding a way of preservation that has no or very little adverse effect on cell adhesion is an important topic. Results from expected advanced researches on cell adhesion may probably find promising applications in the field of tissue engineering.