PCNA,C-erbB-2,Cyclin D1及MMP2的表达与胃癌预后因子的相关性分析
Relationship of expression of PCNA,C-erbB-2,Cyclin D1 and MMP2 in gastric tumor and the relationship with prognosis
摘要
为探讨PCNA ,C erbB 2 ,CyclinD1及MMP2等标志物在胃癌中的表达及其与胃癌预后的相关性。应用免疫组织化学染色法检测 61例胃癌组织中PCNA ,C erbB 2 ,CyclinD1和MMP2的表达 ,并将其与患者的性别、年龄、肿瘤大小、组织分化程度、浸润深度及转移淋巴结数目进行相关性分析。结果示PCNA ,C erbB 2 ,CyclinD 1及MMP2均与肿瘤浸润深度和淋巴结转移数目呈正相关。PCNA和CyclinD 1的表达还分别与肿瘤大小和组织分化程度呈正相关 ,而C erbB 2及MMP2与肿瘤大小及组织分化程度无关。提示肿瘤浸润深度和淋巴结转移数目是影响胃癌预后的最重要的独立危险因子 ;胃癌愈到晚期 ,PCNA ,C erbB 2 ,CyclinD1及MMP2等肿瘤标志物表达愈强 ,从而加速了胃癌的生长与转移。
出处
《中国普通外科杂志》
CAS
CSCD
2004年第4期300-302,共3页
China Journal of General Surgery
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