氟伐他汀对自发性高血压大鼠心血管的保护作用

Experimental study on the protective effect of fluvastatin on cardiovascular system in spontaneously hypertension rats

目的:探讨氟伐他汀对自发性高血压大鼠心血管系统的作用。方法:12周龄自发性高血压大鼠30只,随机分成3组,每组10只:安慰剂组给予安慰剂喂养,氟伐他汀组喂养氟伐他汀20mg/(kg·d);基础组入选后即处死留取血标本检测。分别测量治疗3个月前(后)收缩期血压、体质量、全心质量、左心室质量及血浆血管紧张素Ⅱ、血脂、血糖和尿素氮、肌酐、尿酸水平以及肠系膜三级动脉血管壁/腔面积比。结果:①氟伐他汀组治疗后收缩压(mmHg)均明显下降(163±4),与安慰剂组(174±7)比较,差异有显著性意义(F=3.12,P<0.05)。②氟伐他汀组全心质量和体质量比及左心室质量和体质量比明显下降(全心重/体质量:0.0051±0.0003和0.0049±0.0002;左室质量/体质量:0.0040±0.0003和0.0039±0.0001),与安慰剂组比较,差异有显著性意义(F=2.96,P<0.05)。③氟伐他汀治疗后血管紧张素Ⅱ(ng/L)水平无明显下降(241.50±45.68,F=1.26,P>0.05)。④氟伐他汀治疗后胆固醇(mmol/L)下降(1.23±0.46);三酰甘油水平(mmol/L)也明显变化(1.31±0.23),高密度脂蛋白水平(mmol/L)升高(1.20±0.51),与安慰剂组比较,差异有显著性意义(F=3.39,P<0.05)。⑤氟伐他汀治疗后血糖、血浆尿素氮、肌酐、尿酸水平水平无明显降低作用(F=1.76,P>0.05)。

AIM:To investigate the effects of fluvastatin in protecting the cardiovascular system of spontaneously hypertension rats. METHODS: Thirty spontaneously hypertension rats of 12 weeks old were randomly divided into 3 groups of 10 rats each: placebo group, fluvastatin group[20 mg/(kg·d)] and base group.Rats in the base group were sacrificed before treatment, and blood samples were detected. The systolic blood pressure(SBP),body mass, heart mass(HM), left ventricle mass(LVM),plasma concentration of angiotensin Ⅱ(Ang Ⅱ),lipid,glucose,urea nitrogen, creatinine, uric acid, and mesenteric arteries(3rd grade branch) wall to lumen ratio were determined 3 months before and after treatment respectively 3 months before and after treatment.respectively. RESULTS:①The SBP(mmHg) in the fluvastatins group(163±4) was obviously decreased, significantly different from that in the placebo group(174±7) (F=3.12,P< 0.05). ②The HM/body mass and LVM/body mass ratios in the fluvastatin group (0.005 1±0.000 3 and 0.004 0±0.000 3) were decreased obviously, significantly different from those in the placebo group (0.004 9±0.000 2 and 0.003 9±0.000 1)(F=2.96,P< 0.05).③Ang II level (ng/L) in the fluvastatin group was not significantly changed (241.50±45.68,F=1.26,P >0.05).④In the fluvastatin group, plasma cholesterol was decreased[(1.23±0.46) mmol/L], triglyceride was changed obviously[(1.31±0.23)mmol/L], high density lipoprotein was increased[(1.20±0.51)mmol/L], significantly different from that in the placebo group(F=3.39,P< 0.05). ⑤Plasma glucose, urea nitrogen, creatinine and uric acid in the fluvastatin group had no obvious changes(F=1.76,P >0.05). ⑥Mesenteric arteries W/L ratio was significantly higher in the placebo group (0.69±0.06) than the fluvastatin group(0.42±0.06)(F=3.61,P< 0.05).Fluvastatin can reduce the adverse effects of hypertension on cardiovascular system, and has protective effects on it.