高血压大鼠心肌肥大及逆转过程中相关因素的探讨

STUDY OF CORRELATION FACTORS WITH LEFT VENTRICULAR HYPERTROPHY DURING CARDIAC HYPERTROPHY INDUCED HYPRETENSION AND REGRESSION IN RATS

目的 :探讨在心肌肥大及逆转过程中收缩压 (SBP)、舒张压 (DBP)、平均动脉压 (MAP)、神经肽Y(NPY)等与左心室肥大的关系。方法 :血压和心率用生物信号分析系统记录 ;NPY用放射免疫法测定 ,用SPSS软件求出了相关系数和回归方程。结果 :SBP、DBP、MAP、心肌匀浆中NPY与心系数 (LVW/BW)呈正相关 ,血液中NPY和心率(HR)与心系数不相关。结论 :血压升高是导致左室肥大的因素之一 ,收缩压的影响大于舒张压 ;SBP、DBP、MAP、心肌匀浆中NPY与心系数 (LVW /BW )有相关的趋势。

Aim: To investigate the relations between left ventricular hypertrophy and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure(MAP), neuropeptide Y (NPY) during cardiac hypertrophy and regression. Methods: Blood pressure and heart rate were recorded with polygraph channel biologic message system. NPY in plasm and myocardium were measured with Radioimmunoassay. Correlation coefficient were calculated with SPSS software. There were positive correlations between SBP, DBP, MAP, NPY in the cardiac tissue and cardiac coefficient(LVW/BW). There was no correlations between cardiac cofficent and heart rate(HR)?NPY in plasm.Conclusion: Hypertension is one of cardiac hypertrophy factors,SBP correlate better with LVW/BW than DBP. SBP?DBP?MAP?NPY in cardiac tissue has correlative tendency with LVW/BW.