卡维地洛对家兔急性心肌梗死左室重构的作用(英文)

Effect of carvedilol on left ventricular remodeling after AMI

目的 评价第三代 β -受体阻滞剂卡维地洛对家兔急性心肌梗塞 (AMI)后的左室重构的防治作用 ,以及对梗死区损伤心肌细胞的修复。方法 采用家兔制备心肌梗死模型 ,2 0只AMI术后成活的雄性家兔随机分为AMI对照组、卡维地洛 (CVD)组 ,另设假手术组。灌胃给药 4周后处死动物。用电子精确天平称量左室、右室的重量 ,用羟脯氨酸方法测定心肌组织的胶原的含量及采集标本进行病理分析。结果 梗死后左心室、右心室重量均比假手术组增加 ,差异显著。梗死区胶原含量显著增加 ,非梗死区胶原含量增加明显。经卡维地洛治疗后 ,左心室、右心室重量均下降 ,但未能恢复至正常水平。梗死区胶原含量亦略有下降 ,但差异不显著。非梗死区胶原含量下降明显 ,差异显著。病理分析结果显示卡维地洛组心肌细胞损伤程度减轻。结论 卡维地洛能有效防治家兔AMI后的左室重构及减轻心肌细胞损伤程度。

Objective: To evaluate the effects of the third generation β-blocker, carvedilol, on preventing left ventricular remodeling after acute myocardial infarction(AMI) in rabbits.Methods:After left coronary artery ligation for twenty-four hours, twenty surviving AMI male rabbits were randomly divided into 2 groups: (1) AMI control (n=10) (2) carvedilol control [1 mg/(kg·d), n=10]. Sham-operated group (n=10) was selected randomly as non-infarction control. After 4 weeks of drug therapy by gavages, all the animals were killed and the rabbit hearts were acquired. Left and right ventricular weights were directly measured with exact balance. The contents of collagen in local myocardium were also measured. Then the tissues of the heart were fixed and sampled for pathological analysis.Results: Compared with sham-operated group, the LV weights and RV weights of the AMI group were all significantly increased (P<0.05), and the contents of collagen were significantly increased, too. In comparison with AMI control group, LVWs and RVWs were all significantly decreased (P<0.05) in carvedilol treated group. In carvedilol group, the contents of collagen of infarct zone were insignificantly decreased (P>0.05), but the contents of collagen were significantly decreased (P<0.05) in non-infarct zone after AMI. The damage degree of myocytes was evidently reduced in carvedilol group.Conclusion:Carvedilol has effect on preventing left ventricular remodeling and reducing the damage degree of myocytes after AMI in rabbits, which is worth studying further.