充血性心力衰竭患者甲状腺激素异常变化及其临床意义(英文)

Altered thyroid hormone metabolism and clinic significance in congestive heart failure

目的 探讨充血性心力衰竭患者甲状腺激素异常变化及临床意义。方法 采用放射免疫法检测了 6 4例充血性心力竭 (CHF)患者及 2 8例正常对照者血浆三碘甲状腺原氨酸 (T3 )四碘甲状腺原氨酸 (T4)、反三碘甲状腺原氨酸 (rT3 )及促甲状腺激素 (TSH)的浓度 ,并对CHF患者作了为期 6周的预后观察。结果 CHF患者T3 降低 ,rT3 升高 ,而T4、TSH正常。而且T3 越低 ,T3 /rT3 比值越小 ,心功能愈差 ,预后越差。结论 CHF患者T3 、尤其是T3 /rT3 比值的变化可作为病情程度及短期预后的判断指标。

Objective:To determine the prevalence and clinic significance of abnormal thyroid hormone metabolism in congestive heart failure(CHF).Methods:Free triiodothyronine (T 3) index, free thyroxine (T 4) index, reverse T 3 and thyrotropin levels were analyzed by radioimmune assay. 28 normotensive subjects and 64 patients with CHF were evaluated in the study. And the prognoses of CHF were observed for six weeks.Results:Free T 3 index was reduced,reverse T 3 was elevated, but free T 4 index and TSH were normal in all the patients.The lower free T 3 index was,the smaller the free T 3/ reverse T 3 ratio was,the worse the heart function and prognosis were.Conclusions:Free T 3 index and free T 3 index/reverse T 3 ratio can be the strongest predictors for the grade of illness and short-term outcome in patients with CHF.