血清TNFα与糖尿病患者的关系

Relationship between serum TNFα and diabetic patients

目的 了解糖尿病 (DM )患者与血清肿瘤坏死因子的关系及意义。方法 采用放射免疫法对 75例患者组和 4 3例正常组进行了同步检测TNFα的含量。结果 患者组血清TNFα明显高于正常组并与糖化血红蛋呈正相关 ,且与胰岛素敏感指标呈负相关 ,而DM患者抗谷氨酸脱羧酶抗体阳性组的血清TNFα水平较阴性组有明显增高。结论 糖尿病患者血清TNFα水平的异常增高 ,可推测与长期的糖代谢紊乱、自身免疫性的胰岛损伤及胰岛素抵抗有关。

Objective:To know the relationship and meaning between the serum tumor necrosis factor acpha(TNFα ) and the patients with diabetes mellitus(DM) . Methods: We measured the content of serum TNFα both 75 patients with DM and 43 normal persons by radioimmunoassy. Results: We observed that the serum TNFα of patients are higher than that of the normal persons obviously;the serum TNFα is not only positively relevant to their glycohemoglobin (GHb) lelec but also hegutivly to their insuline sensetivcty; in patients with DM, the sence TNFα is abnormally higher in patients with positive antibody of Glutmaic acid decarbox lase (GAD-Ab) than the patients with no antibody of GAD.Conclusions: We can reason that the high serum TNFα is relative to the long metabobism disorder of glucose self immune injury is insulin and insulin protestimg.