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FDA否决GSK公司的西洛司特用于治疗慢性阻塞性肺病 被引量:1

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作者 郄建坤
出处 《国外医学(药学分册)》 2004年第1期63-63,共1页 Foreign Medical Sciences(Section of Pharmarcy)
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  • 1王永锋,李秀珍.磷酸二酯酶-4抑制剂在支气管哮喘和慢性阻塞性肺病中的临床研究进展[J].临床肺科杂志,2006,11(1):49-52. 被引量:11
  • 2李小明,胡爱虹.磷酸二酯酶抑制剂的药理及临床应用进展[J].安徽医药,2006,10(6):464-466. 被引量:8
  • 3谢诒诚,郑晓亮,钱伯初.磷酸二酯酶-4抑制剂治疗哮喘和慢性阻塞性肺疾病的研究进展[J].世界临床药物,2007,28(1):19-22. 被引量:4
  • 4CARD G L, ENGLAND B P, SUZUKI Y, et al. Struc- tural basis for the activity of drugs that inhibit phos- phodiesterases [ J ]. Structure, 2004, 12 ( 12 ) : 2233 - 2247.
  • 5GIEMBYCZ M A. An update and appraisal of the cilomilast phase III clinical development programme for chronic obstructive pulmonary disease [ J ]. British Journal of Clinical Pharmacology,2006,62 ( 2 ) : 138 - 152.
  • 6GIEMBYCZ M A. Can the anti-inflammatory potential of PDE-4 inhibitors be realized:guarded optimism or wishful thinking? [J]. British Journal of Pharmacolo- gy ,2008,155 ( 3 ) :288 - 290.
  • 7JEWELL.PDE-4抑制剂药物apremilast III期临床实验获积极性结果[EB/OL].http://www.bioon.com/biopharm/ShowArticle.asp?ArticlelD=526324.2012-7-13/2013-1-5.
  • 8BICKSTON S J, SNIDER K R, KAPPUS M R. Teto- milast: new promise for phosphodiesterase-4 inhibi- tors? [J]. Drug Evaluations,2012,21 (12) : 1845 -1849.
  • 9BEEH K M, BEIER J, LERCH C, et al. Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmat- ics and stable copd patients [ J ]. Lung, 2004,182 ( 6 ) : 369 - 377.
  • 10TRALAU-STEWART C J, WILLIAMSON R A, NI- ALS A T, et al. GSK256066, an exceptionally high-af- finity and selective inhibitor of phosphodiesterase-4 suitable for administration by inhalation: in vitro, ki- netic, and in vivo characterization [ J ]. The Journal of Pharmacology and Experimental Therapeutics, 2011, 337(1) :145 - 154.

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