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ER通路信号传导与选择性雌激素受体调节剂耐药机制研究 被引量:2

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摘要 内分泌治疗是乳腺癌综合治疗中的重要措施之一 ,此疗法面临的最大难题是原发性、继发性耐药 ,其确切机制尚不清楚。雌激素受体 (ER)信号传导途径及各辅助因子的分子调控是近年来研究的重点 ,现综述有关研究进展 ,以期为临床选择性ER调节剂 (SERM)
出处 《国外医学(肿瘤学分册)》 2004年第3期163-166,共4页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 1710 64 )
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  • 1Schiff R, Maasarweh S, Shou J, et al. Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate respond. Clin Cancer Res, 2003, 9 ( Pt2 ) : 447s-454s.
  • 2Iwase H, Zhaatg Z, Ornoto Y, et al. Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer. Cancer Chemother Pharmacol, 2003, 52 ( Suppll ) :S34-38.
  • 3Hayashi SI, Eguchi H, Tanimoto K, et al. The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application. Endocr Relat Cancer, 2003, 10(2) : 193-202.
  • 4Liu Z, Auboeuf D, Wong J et al. Coactivator/corepressor ratios modulate PR-mediated transcription by the elective receptor modulator RU486. Proc Natl Acad Sci USA, 2002,99(12) : 7940-7944.
  • 5Graham JD. Pain DL, Richer JK, et al. Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? J Steroid Biochem Mol Biol, 2000,74(5) : 255-259.
  • 6Wu RC, Qin J, Hashimoto Y, et al. Regulation of SRC-3 (pCIP/ACFR/AIB-1/RAC-3/TIUMM-1) coactivator activity by I kappa B kinase. Mol Cell Biol, 2002,22(10): 3549-3561.
  • 7McKenna N J, O' Malley BW. From ligand to respond: generating diversity in nuclear receptor coregulator function. J Steroid Biochem Mol Biol, 2000,74(5): 351-356.
  • 8Ko L, Cardona GR, Iwasaki T, et al. Ser-884 adjacent to the LXXLL motif of coactivator 453S Clinical Cancer Research TRBP defines selectivity for ERs and TRs. Mol Endocrinol, 2002,16( 1 ) :128-140.
  • 9Shang Y, Brown M. Molecular determinants for the tissue specificity of SERMs. Science, 2002,295(5564) : 2465-2468.
  • 10Hudelist G, Czerwenka K, Kubista E, et al. Expression of sex steroid receptor and their co-factors in normal and malignam breast tissue: AIBI is a carcinoma-specific coactivator. Breast Cancer Res Treat, 2003,78(2) : 193-204.

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