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淋球菌外膜抗原的免疫原性 被引量：3

Immunogenicity of gonococcal membrane antigen(a review)
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摘要 淋球菌的唯一宿主是人 ,在漫长的进化过程中淋球菌形成了一套逃避人体免疫系统的机制。尽管如此 ,人们却一直试图筛选有保护作用的淋球茵外膜抗原用于疫苗研究 。 This article recvgnized that study of vaccine should use the gonococcal membrane antigen,and some membrane protein antigen has been discovered now
作者 季明春 陈红菊
机构地区 扬州大学医学院微生物学及免疫学教研室
出处 《皮肤病与性病》 2004年第1期6-8,共3页 Dermatology and Venereology
关键词 淋球菌 外膜抗原 免疫原性 菌毛 IgAl蛋白酶 铁结合蛋白 碳水化合物抗原 奈瑟氏菌表面蛋白A gonococcus membrane antigen immunogenicity review
分类号 R378.16 [医药卫生—病原生物学] R392 [医药卫生—免疫学]
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参考文献16

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  • 2Jerse AE, Crow ET, Bordner AN,et al. Growth of neisseria gonorrboeae in the female mouse tract does not require the gonococcal transferrin or bemoglobin receptors and may be enhanced by commensal lactobacilli[J]. Infect Immun,2002,70(5) :2549 - 2558.
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同被引文献28

  • 1李召东,潘亚平,沈琳,张永华.淋病奈瑟菌外膜蛋白PIA基因原核表达系统的构建及序列分析[J].中国卫生检验杂志,2006,16(5):528-530. 被引量：1
  • 2孙爱华,罗冬娇,胡美多,周晓辉,严杰.淋病奈瑟菌临床菌株PⅠ基因型及PⅠB基因点突变分析[J].中华微生物学和免疫学杂志,2006,26(9):790-794. 被引量：8
  • 3Fisette PL,Ram S,Andersen JM,et al.The lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-B activation in epithelial cells in a toll-like receptor 2-dependent manner[J].J Biol Chem,2003,278(47):46252-46260.
  • 4Hamrick TS,Demsey JA,Cohen MS,et al.Antigenic variation of gonococcal pilin expression analysis of the strain FA1090 polin repertoire and indentification of the pilS gene copies recombing during experimental human infection[J].Microbiology,2001,147(4):839-849.
  • 5Heckels JE,Fletcher JN,Virji M.The potential protective effect of immunization with outer-membrane protein Ⅰ from Neisseria gonorrhoeae[J].J Gen Microbiol,1989,135 (8):2269-2276.
  • 6Wetzler LM,Blake MS,Barry K.Gonococcal porin vaccine evaluation:comparison of Por proteosomes,liposomes,and blebs isolated from rmp deletion mutants[J].J Infect Dis,1992,166(3):551 -555.
  • 7Butt NJ,Virji M,Vayreda F,et al.Gonococcal outer-membrane protein PIB:comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies[J].J Gen Microbiol,1990,136 (11):2165-2172.
  • 8Fletcher JN,Zak K,Virji M,et al.Monoclonal antibodies to gonococcal outer membrane protein Ⅰ:location of a conserved epitope on protein IB[J].J Gen Microbiol,1986,132(6):1611-1620.
  • 9Cooke SJ,Paz H,Poh CL,et al.Variation within serovars of Neisseria gonorrhoeae detected by structural analysis of outer-membrane protein PIB and by pulsed-field gel electrophoresis[J].Microbiology,1997,143(4):1415-1422.
  • 10Fox KK,Thomas JC,Weiner DH,et al.Longitudinal Evaluation of Serovar-specific Immunity to Neisseria gonorrhoeae[J].Am J Epidemiol,1999,149(4):353-358.

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皮肤病与性病
2004年 第1期

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