肺炎衣原体感染与急性冠状动脉综合征关系的临床研究

Clinical evidence in relationship between chlamydia pneumoniae and acute coronary syndromes

通过对近年有关肺炎衣原体(CPn)感染与急性冠状动脉综合征(ACS)关系的临床研究回顾,探讨CPn感染在ACS发病中的作用及抗CPn感染是否对ACS患者的一、二级预防有价值。尽管有大量的临床研究显示,CPn感染与动脉粥样硬化和ACS高度相关,早期抗生素干预临床试验的结果似乎对ACS患者是有益的。但近期一些大规模的随机、双盲、前瞻性、安慰剂对照和多中心研究显示,抗生素治疗对ACS患者没有带来明显的益处。

By reviewing clinical evidence in relationship between chlamydia pneumoniae(Cpn) and acute coronary syndromes(ACS), study the function of Cpn infection in the ACS and the possible value of anti-Cpn infection in preventing ACS of one or second class. Although a large quantity of clinical evidence shows there is a close relationship between Cpn infection and atherosclerosis and acute coronary syndromes,the clinical trial of the antibiotics interference in earlier period proved to be seemingly beneficial to patients with ACS. But in recent period some large-scale randomized,double-blind,placebo controlled trials show that antibiotics treatment for ACS did not bring about obvious advantage.