慢性乙型肝炎患者血清HA、LN、Ⅳ-C、PCⅢ水平与临床分型和病理分期的关系

The Relation of HA、LN、Ⅳ-C、PCⅢ Serum Level of Chronic Hepatitis B Patient between Clinical Typing and Pathological Staging

目的 探讨慢性乙型肝炎患者HA、LN、ⅣC、PCIII水平与临床分型及病理分期的关系 .方法 对 2 0 0例慢性乙肝患者按病毒性肝炎防治方案进行临床分型 .分别采用放免法测定血清HA、LN、Ⅳ -C、PCⅢ水平 .结果 血清HA、LN、Ⅳ -C水平在慢性肝炎中度和病理S3 期时开始明显高于对照组 (p <0 .0 5) ,且随着肝脏炎症和纤维化程度的加重而升高 .结论 HA、LN、Ⅳ -C、PCⅢ可反映肝纤维化程度 ,而且受肝脏炎症的影响 .

Objective To discuss the relation between HA、LN、Ⅳ-C 、PCⅢ serum level of chronic hepatitis B patien and clinical typing、and pathological staging. Methods Clinical typing of 200 chronic hepatitis B patients(liver biopsys were performed on 75 patients) was according to the virus hepatitis prevention and cure program. HA、LN、Ⅳ-C、PCⅢ serum levels were estimated by radio-immunity method. Results HA、LN、Ⅳ-C、PCⅢ serum levels were higher transparently than control group in patients of pathological staging S 3.The more severity and fibrosis of the liver ,the higher serum leve ls of HA、LN、Ⅳ-C、PCⅢ. Conclusions The serum levels of HA、LN、Ⅳ-C、PCⅢ could be affected by inflammation of liver and could reflect the severity of hepatic fibrosis.It seems that the serum levels of PCⅢ could be used as a relative sensitive and reliable marker to diagnose early cirrhosis of liver.