COX-2和iNOS在肺癌组织中的表达及其临床意义

Expression and Significance of Inducible Cyclooxygenase and Inducible Nitric Oxide Synthase in Lung Carcinoma

【目的】研究诱导型环氧化酶(COX-2)和一氧化氮合酶(iNOS)在肺癌组织中的表达及其临床意义。【方法】用免疫组化法检测42例肺癌组织中COX-2和iNOS蛋白表达。【结果】COX-2和iNOS表达的阳性率分别为31%和33%;COX-2表达与术后生存期的长短呈负相关;iNOS与肿瘤组织的分化程度密切相关,分化越低,iN-OS表达越强;COX-2与iNOS表达之间未见相关性。【结论】COX-2和iNOS在肺癌中表达与否与患者的预后相关。

To investigate the expression and significance of inducible cyclooxygenase (COX 2) and inducible nitric oxide synthase (iNOS) in lung carcinoma. The expression of COX 2 and iNOS protein was detected by SP immunohistochemical staining in 42 cases of lung carcinoma. The expression rate of COX 2 and iNOS was 31%and 33%respectively. The expression of COX 2 was negatively correlated with survival time. The expression of iNOS was positively correlated with differentiation, the poorer the differentiation, the more expression of the iNOS protein. No relationship was found between the expression of COX 2 and iNOS. [Conclusion]The expression of COX 2 or iNOS is correlated with the prognosis of lung carcinoma.