普通人群中急性病毒性肝炎危险因素的病例对照研究

A Case-control Study on Risk Factors of Acute Viral Hepatitis in General Population

本文应用配对病例对照研究方法对西安市某区普通人群中急性病毒性肝炎疫情报告病例的危险因素进行了研究。1年间所报告的887例急性病毒性肝炎病例中,508例可供分型,其中甲肝323例(63.6％),乙肝66例(13.0％),非甲非乙型肝炎110例(21.6％),其余9例(1.8％)为甲、乙型肝炎病毒同时感染。对499例三型肝炎进行病例对照研究结果经单因素分析表明:甲肝发病的危险因素主要为病前1个月肝炎接触史(OR=13.2)、不洁饮食史(OR=5.5)和出差旅游史(OR=3.4);乙肝主要为病前半年内肝炎接触史(OR=10.0)、家庭成员既往肝炎史(OR=5.3)和注射史(OR=4.3);非甲非乙型肝炎主要与病前半年内肝炎接触史(OR=3—4)、既往肝炎史(OR=7.7)、不洁饮食史(OR=4.5)和外出旅游史(OR=2.7)有关。多因素(Logistic回归模型)分析结果与单因素分析基本一致。本研究提示,该地区可能存在经肠道传播的非甲非乙型肝炎。

By single factor analysis and Logistic regression analysis, the results of case-control of 499 pairs study show that patients with hepatitis A more of ten had histories of personal contact with hepatitis cases (OR=13.2), of ingesting dirty foods (OR=5.5), and of travelling (OR=3.4); Patients with hepatitis B more often had histories of personal contact with hepatitis cases (OR=10.0), of having hepatitis cases in their families(OR=5.3), and of injecting (OR=4.3); while patients of non-A, non-B hepatitis more often had histories of previous clinical hepati tis course (OR=7.7), of personal contact with hepatitis cases(OR=3.4), of ingesting dirty foods (OR=4.5), and of travelling(OR=2.7).