抚顺市男性肺癌遗传性及个体特征的病例对照研究

Genetic Liability and Individual Characteristics of Lung Cancer in Males in Fushun City

1987年7月至1988年10月在抚顺进行了肺癌危险因素的病例对照研究,共查访了138例男性肺癌患者和1:1配比的医院对照(女性例数较少,本文未做分析),本文着重评价抚顺男性家族癌史、呼吸系统疾病史与肺癌危险性的关系。结果表明,家族肺癌史显著增高肺癌危险性(OR=9.00;95％Cl1.64～49.38),肺癌遗传率为39±9％,家族其它癌史不增高肺癌危险性。有呼吸系统疾病史者患肺癌的危险性为无呼吸系统疾病史者的两倍(OR=2.00,95％Cl1.13～3.54)。

A case-control study of lung cancer risk factors with 138 male cases and hospital-based controls was conducted from July 1987 to October 1988 in Fushun city. The subjects were questioned about their family history of cancers, personal history of respiratory diseases, smoking habit, and other factors. The paper emphatically estimated the association between family history of cancers personal history of respiratory diseases and lung cancer risk The significantly increased risks for the family history of lung cancer (OR=9.00; 95％ CI 1.64 to 49.38) and the personal history of respiratory diseases (OR=2.00; 95％CI 1.13 to 3.54) were observed The geneticratio of lung cancer was 39±9％.