促红细胞生成素治疗早产儿贫血的临床研究被引量：6

Clinical investigation of anemic premature birth infants treated with erythropoietin

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摘要目的观察重组人类促红细胞生成素(rh-EPO)防治早产儿贫血的疗效。方法将46例早产儿按入院顺序随机分为治疗组和对照组各23例,治疗组用rh-EPO每周600 IU／kg,隔天1次,皮下注射共6周,加常规治疗(维生素E 25 mg／d,维生素C 0.2 g／d,元素铁每天6 mg／kg),必要时输血,对照组仅用常规治疗。结果治疗后治疗组网织红细胞计数(Ret)较对照组明显升高(P<0.01);两组早产儿出生后血红蛋白(Hb)均逐渐下降,但治疗组下降缓慢,治疗结束后两组差异非常显著(P<0.001);血清铁水平在治疗期间治疗组明显低于对照组(P <0.01);治疗结束后差异缩小(P<0.05);治疗组输血率(13.04％)较对照组(52.17％)明显减少(P<0.01)。结论 rh-EPO能有效防治早产儿贫血,无明显副作用。

作者顾承萍

机构地区浙江省舟山市妇幼保健院儿科

出处《临床儿科杂志》 CAS CSCD 北大核心 2004年第3期179-180,共2页 Journal of Clinical Pediatrics

关键词促红细胞生成素治疗早产儿贫血 rh-EPO 副作用

分类号 R722.6 [医药卫生—儿科]

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