小剂量尿激酶 肝素治疗不稳定性心绞痛

Low Dose of Urokinase Heparin to Treat Unstability Angina Pectoris

目的 观察小剂量尿激酶联合肝素抗凝治疗不稳定性心绞痛的临床疗效及对病死率和AMI发生率的影响。方法 所选UAP患者 176例 ,随机分两组治疗。对照组 88例。治疗组 88例 ,剂量、时间、疗程同对照组 ,并在常规用药基础上加用小剂量尿激酶 0 5万IU/kg于 6 0min内静脉滴注 ,连滴 3d。结果 治疗组治疗心绞痛的临床显效率 (6 3 6 % )和总有效率 (90 9% )均较对照组 (18 2 % )和 (4 5 5 % )显著提高 (P <0 .0 5 )。两组均有轻度出血倾向 ,但不良反应轻微。结论 可提高心绞痛治疗的总有效率 ,减低其AMI及频发心绞痛的发生率 ,为UAP治疗提供安全方便、疗效迅速可靠的方法。

Objective To observe clinical effect of low dose of Urokinase united with heparin anticoagulatory to treat unstability angina pectoris and influence on death rate and AMI incidence rate.Methods Select UAP patients 176 cases,randomly divided to 2 groups,control group 88 cases.Treatment group 88 cases,dosage,time,course of treatment are same with control group,add low dose of Urokinase 5000IU/kg in 60 minutes for 3 days intravenous injection on routine medication.Results The clinical effective rate(63.6%) and total effective rate ( 90.9% ) of treatment group are higher than (18.2%) and (45.5%) in control group(P<0.05).Both of groups have slightly bleeding tendency,the side reaction is slight.Conclusion It can imporve the total effective rate for angina pectoris,decrease the incidence of AMI and angina pectoris,providing a useful,convenient,rapid and reliable cure for UAP treatment.