大剂量免疫球蛋白和氢化可的松对无效血小板输注的影响

The effect of high dose gammaglubolin and hydrocortisone in patients with platelet transfusion refractoriness

目的 :研究当发生无效血小板输注时大剂量免疫球蛋白和氢化可的松对血小板输注的疗效的影响。方法 :39例出现无效血小板输注的急性白血病患者被分成 3组 ,在再次输注血小板前 ,1 5例患者被输注大剂量免疫球蛋白 ,0 .6g/kg ;1 3例输注 4 0 0mg氢化可的松 ;1 1例为对照组。每个患者输注单采血小板 1 2单位 ,计算各自 1h及 2 4h血小板增加纠正值 (CCI)。结果 :输注免疫球蛋白组的有效率高于对照组 ,P <0 .0 5 ;氢化可的松组和对照组的差别无统计学意义 ,P >0 .0 5。结论 :当出现无效血小板输注时 ,大剂量免疫球蛋白可用于提高血小板输注的疗效。

Objective:To observe the effect of high dose gammaglubolin and hydrocortisone in treating platelet transfusion refractoriness. Methods:39 patients suffered from acute leukemia with platelet transfusion refractoriness were divided into 3 groups before repeating platelet transfusions,15 patients were injected with high dose gammaglubolin,13 cases were injected with hydrocortisone,the other 11 cases as control group. Each patient was then transfused with 12U single-donor platelet,and their corrected count index (CCI) were calculated at 1 and 24 hours after platelet transfusion. Results: The effective rate of gammaglubolin group was higher than the control group;the difference between hydrocortisone group and the control group was no significant. Conclusions:High dose gammaglobulin could improve responses to single donor platelets in patients refractory to platelet transfusions.