T2DM颈动脉粥样硬化与血尿酸关系

The relationship between uric acid and carotid atherosclerosis in T2DM

目的 :探讨 型糖尿病 (T2 DM)患者血清尿酸水平变化与颈动脉粥样硬化的关系。方法 :检测 10 2例 型糖尿病患者病程、空腹血糖、餐后血糖、体质量指数 (BMI)、血压、血清胆固醇、甘油三脂、尿酸、肾功 5项、心脏收缩和舒张功能。按是否有动脉粥样硬化分为 2组。结果 :在 T2 DM并发动脉粥样硬化组血清尿酸水平显著升高 (P<0 .0 1) ,心脏舒张功能显著降低 (P<0 .0 1) ,尿 β2 、α2 微球蛋白 ,AL b排泄增加 (均 P<0 .0 1)。结论 :T2 DM患者颈动脉粥样硬化时血清尿酸水平升高 ,同时伴心脏舒张功能损伤 ,这种尿酸变化可能与肾小管的损伤有关。

AIM: To investigate the association between serum uric acid concentration and carotid atherosclerosis in type 2 diabetes mellitus (T2DM). METHODS:A study of 102 T2DM patients with or without carotid atherosclerosis was performed. Age, duration, free blood glycose(FBG), postprandial blood glycose(PBG), body-mass index(BMI), blood pressure(BP), serum cholesterol(TC), triglyceride(TG), uric acid(UA), serum β 2-microglobulin(β 2-GM), urinary β 2-microglobulin(β 2-GM), urinary α 2 -microglobulin(α 2-GM), albuminuria (Alb), urinary immunoglobulin(Ig), left ventricular systolic and diastolic function were analyzed. RESULTS: The level of uric acid and uriary excretion of β 2-GM, α 2-GM, albuminuria (Alb significantly increased in T2DM patients with carotid atherosclerosis, while left ventricular diastolic function significantly decreased. CONCLUSION: The increased level of serum uric acid was likely associated with the injury of renal tubule.