小剂量胺碘酮治疗室性心律失常疗效与QT间期的相关性

Correlation between efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arrythmias and QT interval

目的 :探讨小剂量胺碘酮治疗室性心律失常疗效与 QT间期的关系。方法 :4 8例室性心律失常患者给予小剂量胺碘酮 ,疗程 4个月 ,观察治疗前后患者室性心律失常有效控制率与 QT间期延长的关系以及不良反应。结果 :4 8例患者治疗有效率高达 90 % ,且维持量小 (14 3± 34m g/ d)。仅 1例出现一过性 T3、T4升高 ,余无其它不良反应。QT间期延长者治疗效果满意 ;QT间期未延长者 ,治疗效果不佳 ,经延长负荷期后可使部分患者 QT间期延长而取得满意疗效。结论 :小剂量胺碘酮治疗室性心律失常的疗效确切 ,维持用量小 ,不良反应少 ,且 QT间期延长者胺碘酮疗效较佳。

AIM: To evaluate the efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arrythmias(VA). METHODS: Forty-eight patients with VA were treated with Amiodarone for four months. A low-loading dose of Amiodarone was given for fourteen days or more. The therapeutic efficacy, QT interval and side-effects were observe. RESULTS: The total effective rate of patients with VA was 89.6%. Only one patient developed hyperthyroidism and recovered after the treatment. No other side-effects due to Amiodarone were observed. The therapy was more effective in patients with QT interval prolongation. If VA was not controlled in patients with normal QT interval, QT interval was prolonged after additional loading dose of Amiodarone and VA was controlled. CONCLUSION: There was obvious therapeutic efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arrythmias. No severe side-effects were found. The maintaining dose was lower. QT interval prolongation was very important for therapeutic efficacy.