肠易激综合征患者睡眠质量特征

Sleep quality in patients with irritable bowel syndrome

目的:探讨肠易激综合征(irritable bowel syndrome,IBS) 患者的睡眠特征及其与精神症状的关系. 方法:采用匹兹堡睡眠指数和症状自评量表-90自评量表对连续就诊的41例符合罗马Ⅱ标准的肠易激综合征患者及同期连续就诊的35例消化性溃疡病患者和37例匹配的正常对照进行测评,并通过回归分析探讨睡眠障碍和精神症状之间的关系. 结果:与正常相比,IBS患者精神症状明显增多(40.2±4.5, t=2.63,P=0.04.7),抑郁(0.64±0.24,t=2.53,P=0.020) 和焦虑(0.67±0.30,t=2.16,P=0.016)积分明显增高; 在IBS患者中,睡眠质量和日间功能显著下降,PSQI和睡眠障碍以及安眠药用量显著增加.IBS患者的强迫症状(t=2.60,P=0.037)和精神因素(t=2.71,P=0.028)积分也明显高于消化性溃疡病患者.多元回归分析显示睡眠质量和多种精神症状呈负相关(R>0.195,P<0.05).

AIM: To investigate the sleep quality in patients with irritable bowel syndrome (IBS) and its relationship with the patients' psychiatric symptoms. METHODS: The quality of sleep and psychiatric symptoms in consecutive 41 patients with IBS according to Rome Ⅱ criteria were measured by Pittsburgh sleep quality index (PSQI) and symptom checklist-90 (SCL-90), respectively. In the meantime, 37 matched heath controls and 35 patients matched patients with peptic ulcer diseases as controls were also evaluated.The relationship between PSQI and psychiatric symptoms was investigated by regression analysis. RESULTS: Compared with health controls, IBS patients had more psychiatric symptoms (40.2±4.5,t =2.63, P=0.047), and higher scores of depression (0.64±0.24, t =2.53, P = 0.020) and anxiety (0.67±0.30,t =2.16, P =0.016). Among IBS patients, the quality of sleep and daily functions significantly decreased. PSQI and sleep disturbances as well as soporific using was markedly increased . The scores of obsessive-compulsive (t =2.60, P =0.037), and mental factor (t =2.71, P=0.028) were higher in IBS patients than that in patients with peptic ulcer diseases. Multiple regression analysis showed negative relarionship between the quality of sleep and many psychiatric symptoms (R > 0.195, P<0.05, respectively). CONCLUSION: IBS patients have sleep disturbances associated psychiatric symptoms.