丹参注射液对妊娠期肝内胆汁淤积症患者脐动脉血流的影响

The Effects of Danseng Injection on Umbilical Artery Blood Flow of Patients with Intrahepatic Cholestasis of Pregnancy

目的 观察丹参注射液对妊娠肝内胆汁淤积症患者脐动脉血流的影响,并进行疗效评价。方法 将符合诊断标准的妊娠肝内胆汁淤积症孕妇84例随机分为治疗组43例,对照组41例。对照组给予常规治疗,治疗组在对照组的基础上加用丹参注射液,以7d为一疗程,观察两组治疗前后脐动脉血流S/D比值和阻力系数RI的变化,评价丹参注射液的疗效。结果 ①治疗组的有效率97.7%,无效率2.3%,OR=7.2,95%CI为1.06～48.86;对照组则分别为85.3%、14.7%、0.14、0.02～0.94。②治疗后的胎儿脐动脉血流S/D比值和阻力系数RI明显下降(P<0.01)。③分娩孕周延长,新生儿体重增加,不增加产后出血及围产儿死亡率。④ARR=12.4%,RR=0.16,RRR=87.6%,NNT=8例。结论 丹参注射液可作为治疗妊娠肝内胆汁淤积症的辅助用药,疗效好,临床价值大。

Objective To observe the effects of Dansen injection on umbilical artery blood flow of patients with intrahepatic cholestasis of pregnancy (ICP), and to evaluate the curative effect. Methods 84 pregnant women with ICP were assigned randomly to treatment group (n=43) and control group (n=41), the treatment group add 20mL Dansen injection based on the control group which using general treatment, one observe period of treatment is 7 days. The variety of systolic/diastolic ratio (S/D) and resistance index (RI) of umbilical artery were observed in two groups before and after treatment. Results ①The efficiency is 97.7%, inefficiency is 2.3%, OR=7.2 and 95%CI is 1.06～48.86 for Dansen injection treatment group, corresponding data of control group are 85.3%,14.7%,0.14 and 0.02～0.94 respectively. ②After treatment with Dansen injection, S/D and RI of umbilical artery blood flow decreased significantly compared with control group and before treatment (P<0.01). ③Both gestational age and weights of infants increased, the flooding and the death rate of infants not increased. ④ARR=12.4%, RR=0.16, RRR=87.6%, NNT=8. Conclusions As a assistant drug to be used in intrahepatic cholestasis of pregnancy treatment, the curative effect of Dansen injection is obvious.