健肾片对IgA肾病模型大鼠肾组织一氧化氮、一氧化氮合酶含量的影响

Effects of Jianshen Tablet on NO and NOS in the Renal Tissue in the Rat with IgAN

目的 观察健肾片对IgA肾病大鼠肾组织一氧化氮(NO)、一氧化氮合酶(NOS)含量的影响,探讨健肾片对IgA肾病的作用机理。方法 采用口服牛血清白蛋白和葡萄球菌肠毒素B感染的复合方法,复制大鼠IgA肾病模型,并分别给予健肾片和雷公藤多苷片治疗,经硝酸还原法检测肾组织的NO、NOS含量。结果 健肾片可明显降低IgA肾病大鼠肾组织的NO、NOS含量。结论 健肾片治疗IgA肾病的作用机理之一是降低IgA肾病肾组织的NO、NOS含量。

Objective To observe the effects of Jianshen Tablet on NO、NOS in the renal tissue in the rat with IgAN and to explore the effective mechanism of Jianshen Tablet on treating IgAN. Methods The models of the rat with IgAN were set up by the compound way of BSA p.o. and SEB injection. They were treated with Jianshen Tablet and CTW respectively. Their renal tissue NO, NOS were examined with nitrite reduction test. Results Jianshen Tablet significantly reduced the NO、NOS in the renal tissue of the rat with IgAN. Conclusion It is one of effective mechanism of Jianshen Tablet on treating IgAN that the precription reduced NO, NOS in the renal tissue of IgAN.