奥美拉唑为主的三联疗法治疗反流性食管炎临床观察

<title>fect of Combination Therapy of Omeprazole and Domperidone and Sucralfate on Reflux Esophagitis

目的:观察奥美拉唑联合多潘立酮(吗丁啉)、硫糖铝治疗反流性食管炎(RE)的临床效果。方法:将82例经内镜等检查诊断的RE患者随机分为两组:治疗组42例,应用奥美拉唑20 mg、2次／d,吗丁啉10 mg、3次／d,硫糖铝1.0 g、4次／d治疗;对照组40例,用雷尼替丁150 mg、2次／d,吗丁啉及硫糖铝(用法同治疗组)。两组疗程均为6周。记录症状积分。疗程结束复查内镜。结果:治疗组临床总有效率95.2％,优于对照组的80.O％(P<0.01);治疗组反酸症状的改善优于对照组(P<0.05),其余症状的改善两组比较无统计学意义(P>0.05)。胃镜下食管粘膜病损显效率与总有效率,治疗组为81.0％及97.6％,对照组为55.0％及82.5％。两组比较均有统计学意义(P<0.01)。结论;奥美拉唑与吗丁啉、硫糖铝联合用药是目前治疗RE较为理想的一种有效疗法。

<abstract>jective:To investigate the effect of Omeprezole, Domperidone and Sucralfate on reflux esophagitis(RE). Methods: Eighty-two patients with endoscopically-proven RE were randomly divided into two groups. In the treatment group of forty-two patients, Omeprazole was given 20mg twice a day, combined with Domperidome 10 mg three times a day and Sucralfate 1. 0 g four times a day. In the control group, Ranitidine of 150 mg twice a day was used to replace Omeprazole, Domperidone and Sueralfate were given the same as the treatment group. Treatment course of both groups were six weeks. Before and after the treatment, reflux symptoms were evaluated. At the end of the treatment, endoscopic exam was redone. Results:Clinical effective rate of the treatment group was better than that of the control group ( P <0. 01). Endoscopic exam showed that the obviously effective rate of the treatment group and the control group was 81. 0% and 55. 0% respectively; whole effective rate was 97. 6% and 82. 5% respectively, which showed significant difference between the two groups ( P <0. 01). Conclusion: Combination of Omeprazole, Domperidome and Sucralfate was an effective therapy to treat RE at present.