吗啡依赖大鼠长期戒断后的觅药行为与伏膈核Fos表达

MORPHINE PREFERENCE FOLLOWING PROLONGED ABSTINENCE ASSOCIATION WITH FOS EXPRESSION IN THE NUCLEUS ACCUMBENS

目的 :研究吗啡依赖大鼠长期停药后的觅药行为和伏膈核各亚区 (外壳区、核心区 )的Fos蛋白表达。方法 :大鼠皮下注射吗啡使其成瘾 ,停药 2月后进行条件性位置偏爱试验 ,并检测伏膈核核心区和外壳区的Fos蛋白表达。结果 :吗啡预处理组大鼠的位置偏爱效应明显强于盐水预处理组 ,在伏膈核核心区的Fos蛋白表达显著高于对照组。结论 :位置偏爱行为与吗啡相关环境刺激引起伏膈核核心区的激活有关 。

Objective :To observe the drug-seeking behaviour in abstinent rats which were chronically morphine-pretreated and determine NAc core and shell involved in this behavior. Methods : Preferences for morphine-associated environments and Fos expression in NAc core and shell were measured 35 days after withdrawal of chronic morphine treatment. Results : The preference for the morphine environment was greatly increased by morphine pretreatment. The morphine pretreated group showed significant higher Fos levels than the control groups in the NAc core. Conclusion : There is a relationship between conditioned place preference behavior and neural indices of activation in the NAc core in response to morphine-conditioned cues, which may be chronically modulated by prior morphine exposure.