摘要
为探讨充血性心力衰竭患者(CHF)血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、一氧化氮(NO)、内皮素(ET-1)、心钠素(ANP)的改变及健心汤的临床效应。将66例CHF患者随机分为试验组和对照组。对照组采用常规治疗,试验组在常规治疗的基础上加用益气温阳、活血利水中药健心汤。两组疗程均为四周。在治疗前后测定TNF-α、IL-6、NO、ET-1、ANP和心功能的变化。结果:治疗后两组血清TNF-α、IL-6、NO、ET-1、ANP水平均明显下降(P<0.05,或P<0.01),且试验组较对照组降低更为显著(P<0.05)。治疗后两组心功能均有明显改善(P<0.05,或P<0.01)。提示健心汤可能通过调控细胞因子的水平、减轻机体神经内分泌的过度激活,起到防止和逆转心室重构,改善心功能的作用。
To investigate the effects and clinical efficacy of 'Jianxin Decoction' on TNF-pppppp,IL-6,NO,ET-l and ANP in the treatment of patients with congestive heart failure (CHF) ,66 cases were randomized into two groups: control group in which routine treatment was given and observation group in which 'Jianxin Decoction' was given as well as routine treatment. Both groups were treated for 4 weeks. The TNF-α, IL-6, NO, ET-1, ANP and heart function were measured before and after treatment. Results : After treatment, TNF-α, IL-6, NO, ET-1 and ANP reduced obviously in both groups ( P < 0.05,P<0.01) ,more significantly in observation group (P <0.05) ;the heart function strikingly improved (P <0. 05 ,P <0. 01). It is revealed that the Decoction can regulate cell factors and diminish neuroendocrine to prevent and reverse ventricle reconstruction and heart function.
出处
《上海中医药大学学报》
CAS
2004年第1期17-20,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
广东省博士后基金资助项目([2002]523)
