原发性肝癌肝胆湿热证量化标准研究

Quantified Standards for Liver-Gallbladder Dampness-Heat Syndrome of Primary Liver Cancer

为建立原发性肝癌肝胆湿热证量化标准(包括量化诊断标准和程度分级标准)。在流行病学调查的基础上,以肝胆湿热证辨证参考标准进行辨证,根据相关因素在肝胆湿热证组和非肝胆湿热证组中出现状况的差异对相关因素进行赋分,并以此为基础建立量化诊断标准,对量化诊断标准进行检验,建立程度分级标准。结果:原发性肝癌肝胆湿热证量化诊断标准为26分;量化诊断标准回顾性和前瞻性检验的敏感度、特异度、准确度均在90％以上,阳性似然比分别为12.68和11.78;程度分级标准:轻度26-35分,中度36-45分,重度≥46分。提示原发性肝癌肝胆湿热证量化标准同以往建立的各种形式的肝胆湿热证标准相比较更符合原发性肝癌的临床实际,统计更严谨,相关因素赋分更合理,验证更严谨,更具有临床实用价值。

This article establishes the quantified standards for liver-gallbladder dampness-heat syndrome of primary liver cancer. On the basis of epidemiological survey, the factors related to the syndromes of and of no liver-gallbladder dampness-heat are quantified and scored,hence to set up the standards. Results:The diagnostic standard for liver-gallbladder dampness-heat was 26 points;its retrospective and prospective sensitivity,specificity and accuracy were over 90% ; positive ratios were 12. 68 and 11.78; grading standards were 26 - 35 points for mild syndrome ,36 - 45 points for moderate syndrome , and over 46 points for severe syndrome. It is showed that this standard is of more practice and value.