劳拉西泮与多虑平治疗焦虑症临床疗效比较

Comparisons of clinical efficacy between serenase and sinequan in anxiety

目的 比较劳拉西泮与多虑平对焦虑症的疗效及副作用。方法 随机将入组的56例患者分为劳拉西泮组和多虑平组,每组28例,分别以劳拉西泮与多虑平进行为期4w的治疗。以HAMA、TESS于疗前及疗后各周分别评定1次,以X2检验、t检验对统计结果进行统计学处理。结果显效率:劳拉西泮组为71.4％,多虑平组为67.9％,两组间比较无显著性差异(x2=0.085,P>0.05);疗后2w起,两组HAMA评分均呈显著性下降,但治疗各周两组之间HAMA评分比较无显著性差异(P>0.05),显示二种药物疗效相当,但TESS评分于治疗各期均存在显著性差异(P<0.05～0.01),提示劳拉西泮的副反应明显轻于多虑平。多虑平主要有抗胆碱能副作用及心血管系统反应,劳拉西泮在此方面轻微,而以头昏、疲劳多见。结论罗拉是一种理想的抗焦虑药物。

Objective To compare efficacy and side effects between serenase and sinequan in anxiety. Methods 56 patients were randomly divided into serenase and sinequan groups (each n = 28) and treated for 4 weeks, and assessed with HAMA and TESS before treatment and in each week of treatment, statistic results used %2 and f2 tests. Results Effectual rates of serenase and sinequan were 71. 4,% and 67. 9% respectively, which showed no significant difference(%2 =0. 085,P>0. 05); From 2nd week of treatment, the scores of HAMA of both 2 groups obviously decreased, but that showed no significant difference (P>0. 05),which exhibited that efficacies of the 2 drugs were equivalent; the scores of the TESS showed significant difference in each week(P<0. 05-0. 01) , which suggested that the side effects of serenase were obviously milder than that of sinequan. The side effects of sinequan were mainly anticholinergic and cardiovascular responses, that of serenase milder and mainly dizziness and fatigue. Conclusion Serenase is an ideal antianxietic.