C-erbB-2、MMP2在乳腺癌中的表达及相互关系探讨

A Study of the Expression of C-erbB-2 and MMP2 and Their Relationship in Invasive Ductal Carcinoma of Breast

目的 :探讨癌蛋白 (C erbB 2 )和基质金属蛋白酶 (MMP2 )在乳腺浸润性导管癌中的表达及相互关系。方法 :应用免疫组织化学S -P法对 5 6例乳腺浸润性导管癌的C erbB 2和MMP2的阳性表达进行检测分析。结果 :5 6例中有 37例 (6 6 % )C erbB 2过表达 ,39例 (6 9.6 % )MMP2过表达 ,C erbB 2和MMP2同时阳性表达者 32例(5 7 1% )。两者阳性率均随组织学分级升高而上升 ,但各级间未见明显差异 (P >0 .0 5 )。在转移组中 ,88.9% (2 4 /2 7)的病例C erbB 2过表达 ,85 .2 % (2 3/ 2 7)MMP2过表达 ,两者的过表达与转移呈正相关关系 (PC erbB 2 =0 .0 0 1,PMMP2 =0 .0 15 )。C erbB 2和MMP2阳性配对分析表明 ,两者间阳性表达互为正相关 (P <0 .0 0 5 ,r=0 .5 1)。结论 :在乳腺浸润性导管癌中 ,C erbB 2和MMP2的过表达提示转移增加 ,可以作为乳腺癌的预后指标。

Objective:To study the expression of C erbB 2 and MMP2 in invasive ductal carcinoma of the breast and their relationship. Method:56 cases of breast invasive ductal carcinoma were examined for the expression of C erbB 2 and MMP2 by using immunohistochemical method. Result: The positive rates of C erbB 2 (37/56,66%) and MMP2(39/56,69.6%) were increased with higher grades (60%,66.7%,73.3% in grades I,II,III for C erbB 2;60%,71.4%,80% in grades Ⅰ,Ⅱ,Ⅲ for MMP2),but no statistical difference was seen( P >0.05). The overexpression of C erbB 2(88.9%) and MMP2(85.2%) was show positively related with axillary lymph node metastasis(PC erbB 2=0.001,PMMP2=0.015). There was a positive relationship between the overexpression of C erbB 2 and MMP2( P<0.005,r=0.51). Conclusion:The overexpression of C erbB 2 and MMP2 in invasive ductal carcinoma of breast indicated a higher propensity of tumor metastasis,and can be used as a prognostic marker for metastasis in breast cancer.