重症肌无力伴甲状腺功能减退(附24例报告)

Myasthenia Gravis Concomitant with Primary Hypothyroidism

目的 探讨重症肌无力 (myasthenia gravis,MG)与原发性甲状腺功能减退两病并存的临床特点、发病机制和治疗方法。方法 对 1 95 6— 2 0 0 1年间同济医院确诊的 2 5 89例 MG患者中伴原发性甲状腺功能减退的 2 4例患者的临床和实验室资料进行回顾性分析。结果 全部 MG患者中 ,两病并存者占 0 .9% ,其中女性发病率为83 .3 % ,成年人占 75 .0 % ,全身型占 70 .8% ,危象发生率为 2 5 .0 %。两病同时治疗效果明显优于仅对一病治疗。结论 MG伴发甲状腺功能减退以成年女性较多且病情较重 ,早期诊断和两病同时治疗是取得疗效的关键。

Objective To study the clinical characterisitics,pathogenesis and therapy of myasthenia gravis concomitant with primary hypothyroidism. Methods Retrospective study was done on 24 patients of myasthenia gravis concomitant with primary hypothyroidism of the 2 589 myasthenia gravis that diagnosed in Tongji hospital from 1956 to 2001. Results (1)The rate of myasthenia gravis concomitant with primary hypothyroidism is 0.9%. Among the 24 cases,20 patients(83.3%)were femal, 18 patients (75.0%) were adult, 17 patients (70.8%) were classified in groupⅡ,Ⅲ and Ⅳ, 6 patients (25.0%) had onsetofmyastheniacrisis;(2)The effect of therapy to both disease was better than to either. Conclusions (1)Myasthenia gravis concomitant with hypothyroidism often come on adult femal. The patient's conditon is severer than without hypothyroidism.(2)It's a key of obtaining curative effect to diagnose early and treat the 2 illness at the same time.