阿尔茨海默病与血管性痴呆的胼胝体MR定量研究

Quantitative MR study of corpus callosum in Alzheimer′s disease and vascular dementia

目的 比较MR影像上阿尔茨海默病 (Alzheimer′sdisease ,AD)组、血管性痴呆 (vasculardementia ,VD)组、正常对照 (normalcontrol,NC)组胼胝体面积及胼胝体不同部位的厚度 ,为进一步探讨AD、VD的发病机理提供参考。方法 本研究 70例中AD 2 6例 ,VD 14例 ,年龄匹配的正常对照 3 0例。行磁共振扫描 ,取T1WI正中矢状面测量胼胝体面积及胼胝体前、前中、中、中后、后 5个部位的厚度。结果 AD组与VD组及NC组胼胝体标准化面积分别为 :(3 5 5± 0 5 2 )cm2 ;(3 48± 0 90 )cm2 ;(4 2 3± 0 43 )cm2 。AD组与VD组及NC组胼胝体前、前中、中、中后、后 5个部位标准化厚度分别为 :AD (5 3 4± 1 14)mm ,VD (5 5 3± 1 86)mm ,NC (7 0 6± 1 11)mm ;AD (2 5 3± 0 62 )mm ,VD (2 5 3±0 86)mm ,NC (3 46± 0 66)mm ;AD (2 85± 0 5 4)mm ,VD (2 84± 1 0 4)mm ,NC (3 5 4± 0 61)mm ;AD (2 0 1± 0 5 0 )mm ,VD (1 90± 0 72 )mm ,NC (2 49± 0 65 )mm ;AD (5 46± 0 96)mm ,VD (5 2 2±1 40 )mm ,NC (6 82± 1 0 2 )mm。AD组与VD组胼胝体前、前中、中、中后、后 5个部位的萎缩率分别为 :AD (2 4 3 6± 16 13 ) % ,VD (2 1 70± 2 6 3 5 ) % ;AD (2 6 75± 17 97) % ,VD (2 6 78± 2

Objective To investigate the total area and different portions of corpus callosum in Alzheimer′s disease (AD), vascular dementia (VD), and normal contrast(NC) Methods 70 cases which contained 26 AD patients, 14 VD patients, and 30 age matched control subjects received MRI Total area and five regional (anterior, anterior middle, middle, posterior middle, and posterior portions) thickness of corpus callosum were measured on T 1 weighted mid sagittal slices Results The standardized total area of corpus callosum in AD, VD, and NC groups were (3 55±0 52) cm 2,(3 48±0 90 ) cm 2,and (4 23±0 43 ) cm 2, respectively And the five regional thickness of corpus callosum in AD, VD, and NC groups were:AD (5 34±1 14) mm, VD (5 53±1 86) mm, NC (7 06±1 11) mm; AD (2 53±0 62) mm, VD (2 53±0 86) mm, NC (3 46±0 66) mm; AD (2 85±0 54) mm, VD (2 84±1 04) mm, NC (3 54±0 61) mm; AD (2 01±0 50) mm, VD (1 90±0 72) mm, NC (2 49±0 65) mm; AD (5 46±0 96) mm, VD (5 22±1 40) mm, NC (6 82±1 02) mm, respectively The five regional atrophy rate of corpus collosum in AD and VD were: AD(24 36±16 13)%, VD(21 70±26 35)%; AD(26 75±17 97)%, VD(26 78±24 90)%; AD(19 60±15 30)%, VD(19 72±29 24)%; AD(19 17±20 35)%, VD(23 79±28 99)%; AD(20 00±13 96)%, VD (23 44± 20 60)% respectively Both the standardized total area and five regional thickness of corpus callosum in AD and VD groups were significantly decreased comparing with those of NC group ( P <0 01) No differences were found between AD and VD groups ( P >0 05) There were no statistical differences among the five regional atrophy rate of corpus collosum both in AD and VD groups ( P >0.05).Conclusion Significant corpus callosum atrophy can be detected in both AD and VD patients, indicating that interhemispheric cortico cortical disconnections may contribute to AD and VD