伐昔洛韦抑制疗法和间歇疗法预防生殖器疱疹复发作用比较

Comparative Study of Suppressive and Intermitant Valaciclovir Therapy for Preventing Genital Herpes Recurrence

目的 比较伐昔洛韦每日抑制疗法和间歇疗法对预防生殖器疱疹复发的作用。方法 65例复发性生殖器疱疹患者按不同复发频度分层后以半随机方式分配至间歇疗法组 (A组 )和每日抑制疗法组 (B组 )。A组 3 4例 ,当疱疹复发时口服伐昔洛韦 3 0 0mg ,2次 /d ,连服 6天 ;B组 3 1例 ,口服伐昔洛韦 3 0 0mg ,1次 /d ,连服 4个月。治疗后观察随访 6个月。结果 在 4个月治疗期间以及其后 6个月随访期间 ,B组每半年平均复发次数均显著低于A组 (P均 <0 .0 0 1)。结论 伐昔洛韦每日抑制疗法对预防和延迟生殖器疱疹复发具有显著作用 ,疗效明显优于间歇疗法。

Objective To compare the preventing and delaying efficacy of suppressive and intermitant valaciclovir therapy for genital herpes recurence.Methods 65 patients with recurrent genital herpes were firstly stratified according to their different frequency of recurence,and then hemi-randomly divided into two groups:the intermitant treatment group(group A)and the suppressive therapy group(group B).For the 34 cases of group A,valaciclovir was given 300 mg,twice daily for 6 days only when the herpes relapsed.For the 31 cases of group B,valaciclovir was given 300 mg once daily consecutively for 4 months. Both groups were followed-up for 6 months after the 4-month treatment. Results The average recurrent times per six months of group B was significantly lower than that of group A during both the 4-month treatment time and the thereafter 6-month follow-up period( P <0.001).Conclusion The suppressive therapy of valaciclovir has good effect for preventing and delaying genital herpes recurrence,and is significantly better than the intermitant treatment.