应用St George′s呼吸问卷评价我国慢性阻塞性肺疾病患者生活质量的价值

Application of St George′s respiratory questionnaire in evaluating the life quality of Chinese patients with chronic obstructive pulmonary disease

目的 应用StGeorge′s呼吸问卷 (SGRQ)评价我国慢性阻塞性肺疾病 (COPD)患者生活质量的价值。方法 对 30例COPD患者进行SGRQ评分及肺功能测定 ,并对其结果作相关性分析 ,计算Pearson′s相关系数评价SGRQ的有效性。其中 19例患者经吸入糖皮质激素治疗 3个月后完成随访 ,并将其治疗前、后SGRQ评分和肺功能结果进行配对t检验 ,评价SGRQ对COPD病情变化的敏感性。结果 SGRQ的呼吸症状、活动受限和疾病影响三个能区的分值与总分相关系数分别为 0 6 1、0 79、0 97,而呼吸症状、活动受限、疾病影响、SGRQ总分与一秒钟用力呼气容积占预计值百分比(FEV1占预计值 % )的相关性较好且基本相似 (Pearson′s相关系数为 - 0 4～ - 0 5 ,P <0 0 5 )。表明吸入糖皮质激素治疗前、后SGRQ比较评分有明显改善 (P <0 0 0 1) ,与临床症状、肺功能改善一致 ,且较肺功能改变更敏感。结论 SGRQ是评价我国COPD患者生活质量有效、敏感、可行的方法 ,值得在我国推广。

Objective To study the value of St George′s respiratory questionnaire (SGRQ) in evaluating the life quality of Chinese patients with COPD. Methods The SGRQ score and spirometry were collected from 30 patients with COPD. The validity was documented by performing correlation analysis, and Pearson′s correlation coefficients were calculated.Nineteen patients were reassessed after three months′ treatment with inhaled glucocorticoids. Paired t test was performed to evaluate the sensitivity of SGRQ to changes of disease severity. Results The correlation coefficients between the total score and the symptoms section score, the activity section score, and the impacts section score of SGRQ were 0.61,0.79 and 0.97, respectively. The symptoms section score, the activity section score, the impacts section score, and the total score were significantly correlated with FEV_1 %pred, and with similar coefficients (-0.4～-0.5, P <0.05 ). The result of paired t test showed that the changes of SGRQ between the two assessments were significant ( P <0.001 )and consistent with changes of clinical symptoms and spirometry. SGRQ was more sensitive than spirometry in evaluating the changes of disease severity. Conclusion SGRQ was a valid, sensitive and feasible method in measuring the quality of life in Chinese patients with COPD. Large-scale application in China needs to be carried out.