期刊文献+

大环内酯类免疫抑制剂在皮肤科的研究与应用 被引量:6

New development of macrolide immunosuppressant in the treatment of skin diseases
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摘要 大环内酯类免疫抑制剂是一组新的具有大环内酯结构的免疫抑制剂,经体内外研究证明该类药物具有明显的免疫抑制作用,其中包括他克莫司、子囊霉素及其衍生物匹美克莫司、西罗莫司等,不仅可内服还可外用,故对一些皮肤病如特应性皮炎、银屑病、坏疽性脓皮病、扁平苔藓、接触性皮炎和斑秃等均有一定疗效,该文介绍其作用机制、临床前和临床应用研究进展。
机构地区 中国医学科学院
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2003年第10期620-622,共3页 Journal of Clinical Dermatology
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参考文献5

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同被引文献49

  • 1农祥,何黎,万屏,邹勇莉,刘玲,郭晋.昆明山海棠抗接触变应性光皮炎的研究[J].中华皮肤科杂志,2004,37(10):592-594. 被引量:7
  • 2王静,尹广.雷帕霉素在肾移植中的临床应用[J].肾脏病与透析肾移植杂志,2005,14(4):387-392. 被引量:2
  • 3王晓情.西罗莫司的研究进展[J].医学综述,2006,12(21):1338-1340. 被引量:3
  • 4胡雅玉,任小丽.咪唑斯汀联合他克莫司软膏治疗颜面再发性皮炎疗效观察[J].中国皮肤性病学杂志,2007,21(6):380-381. 被引量:12
  • 5BOSS V, WANG X, KOPPELMANI F, et al. Histamine induces nuclear factor of activated T cell-mediated transcription and cyclosporinesensitive interleulin-8 Mrna expression in human umbilical vein endothelial cell [ J]. Mol Pharmacol, 1998, 54 ( 2 ) :264 - 272.
  • 6DUMONT F J. FK506 , an immunosuppressant targeting calcineurin function[J]. Curr Med Chem,2000,7(7) :731 -748.
  • 7WOLLENBERG A, SHARMA S, VON BUBNOFF D,et al. Topical tacrolimus(FK506) leads to profound phenotypic and functional alterations of antigertpreseming dendritic cells in atopic dermatitis[ J]. ] Allergy Clin Immunoi ,2001,107 (3) :519 - 525.
  • 8KOHYAMA T, TAKIZAWA H, KAWASAKI S, et al. A potent immunosuppressant FKS06 inhibits IL-8 expression in human eosinophils [J]. nol Cell Biol Res Commun, 1999,1 ( 1 ) :72 - 77.
  • 9KELLY P A, GRUBER S A, BEHBOD F, et al. Sirolimus, a new, potent i mmunosuppressive agent [ J ]. Pharmacotherapy, 1997, 17 (6) : 1148 - 1156.
  • 10NGHIEM P,PEARSON G,LANGLEY R G. Tacrolimus and pimecrolimus : From clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis [ J]. J Am Acad Dermatol,2002 ,46 :228 - 241. 2004:20 : 191 - 199.

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