中枢神经细胞瘤临床病理分析

A clinicopathological study of central neurocytoma

目的:探讨中枢神经细胞瘤(CNC)的临床及病理特征,以提高对此瘤的认识,避免误诊。方法:应用光镜检查观察了4例CNC的组织病理特点,应用免疫组织化学染色观察了突触素(Syn)、神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)和嗜铬蛋白A(CgA)在CNC中的表达情况。结果:本组病例年龄16～33岁,平均22.75岁。肿瘤均发生于侧脑室。CNC组织学特点:瘤细胞由一致的小圆形细胞组成,胞浆透明,呈分房状结构,特征性改变为出现无核纤维岛。免疫组织化学染色Syn、NSE阳性反应。结论:免疫组织化学和电镜对确诊CNC很重要,本瘤治疗以手术全切为首选,预后良好,是分化好的神经元细胞形成的良性肿瘤。

Objective: Purpose To investigate the clinical and pathological characteristics of central neurocytoma ( CNC) so as to further realize the tumor and avoid misdiagnosis. Methods: The histopathological and immunohistochemical features of CNC were studied by immunohistochemical stain for synaptophysin (Syn) , neuron specific enolase (NSE) , glial fibrillary acid protein (GFAP) and ehromogranin A(CgA). Results: The age of the cases ranged from 16 to 33 (average 22.75 years) with all tumors localized in the lateral ventricles. Histologically, all tumors were composed of small uniform round cells with clear cytoplasm and had honeycomb apperance, cell-free islands of neuropil matrix. Immunohistochemical study demonstrated strong positive for Syn and NSE. Conclusions: The importance of immunohistochemical and electron microscopic studies for diagnosis in CNC is emphasized. The first choice of treatment is complete resection and the prognosis is favorable. Central neurocytoma is a kind of benign neoplasm with well-differentiated neuronal cell.