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山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析 被引量：8

Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
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摘要 为探讨宿主的遗传背景和幽门螺杆菌(Helicobacterpylori,H.pylori)相关胃癌的易感性之间的关系,本文采用PCR产物直接测序和PCR-RFLP的方法,检测142例山东临朐县胃癌高发人群个体(包括69例癌症患者和73例非癌个体)和93例北京正常对照个体SE基因多态性的分布特点。结果显示:sew/sew基因型在山东非癌个体和北京人群之间的分布差异具有统计学意义(P<0.01,OR=3.06,95%CI,1.28～7.30),sew/sew基因型在山东癌症病人和非癌个体之间分布频率无显著性差异,H.pylori感染状况与SE基因型的分布也无关联性。提示:sew/sew纯合突变在山东临朐人群中分布频率较高,可能为临朐人群的遗传标记之一。 To study the relation between host genetic backgroud and the susceptibility to H.pylori associated gastric cancer,PCR-sequencing and PCR-RFLP were used to screen SECRETOR gene polymorphisms in 142 subjects including 69 cancer patients and 73 noncancer individuals from highrisk area of gastric cancer in Shandong and 93 control individuals from Beijing.Results showed that the difference in sew/sew distribution between noncancer individuals and Beijing population was significant(P<0.01,OR is 3.06,95% CI,1.28～7.30),but that between cancer patients and noncancer individuals was not with significance.SE gene polymorphism was not relevant to H.pylori infection.We concluded that Shandong population from highrisk area of gastric cancer shared a high distribution of sew/sew genotype,which could be considered as one of the genetic markers.
作者 姜劲迈 潘凯枫 马峻岭 宁涛 路桂荣 游伟程 柯杨
机构地区 北京市肿瘤防治研究所北京大学临床肿瘤学院
出处 《遗传》 CAS CSCD 北大核心 2003年第3期261-266,共6页 Hereditas（Beijing)
基金 国家973重大项目基金资助(1998051203)~~
关键词 山东临朐 胃癌 高发人群 北京人群 Lewis血型抗原 SECRETOR基因 基因多态性 幽门螺杆菌 遗传标记 gastric cancer Lewis blood group antigen SECRETOR gene gene polymorphism
分类号 R735.2 [医药卫生—肿瘤]
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参考文献16

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共引文献868

同被引文献32

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