摘要
目的:考察不同pH条件下2-羟丙基-β环糊精对桂利嗪的增溶作用。方法:在37℃运用相溶解度法进行增溶实验,采用紫外分光光度法测定桂利嗪的浓度。结果:随着2-羟丙基β-环糊精浓度增加和pH的减小,桂利嗪的溶解度显著提高。计算了不同pH下包合物的表观稳定常数。结论:对于难溶性药物桂利嗪,2-羟丙基β-环糊精是较理想的增溶剂。
Objective: To study the solubilization effect of 2-hydroxypropyl-β-cyclodextrin on cinnarizine at various pH value. Methods: Phase-solubility method was adopted to study the solubilization effect at 37℃ and UV spectrohotometer was used to determine cinnarizine. Results: The apparent solubility of cinnarizine was significantly enhanced by increased HPCD concentration and decreased pH value and the apparent solubility constant was calculated. Conclusion: HPCD is an ideal solubilizer for cinnarizine.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2004年第3期233-235,共3页
Chinese Journal of New Drugs
基金
国家九五重点科技攻关项目(96-902-02-09)
