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阿托伐他汀对动脉粥样硬化兔肿瘤坏死因子-α和增殖细胞核抗原表达的影响 被引量：1

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摘要 为探讨阿托伐他汀对粥样硬化家兔增殖细胞核抗原 (PCNA)和肿瘤坏死因子 -α(TNF-α)表达的影响 ,将 18只家兔随机分为 :正常对照组、动脉粥样硬化 (AS)模型组和阿托伐他汀组 ,每组 6只。采用高脂饮食喂养法建立 AS模型 ,饲养 12周后处死 ,取胸主动脉行 HE染色 ,免疫组化染色法检测 PCNA和 TNF-α的抗原表达。结果显示 ,阿托伐他汀可以显著降低粥样硬化主动脉组织PCNA和 TNF-α的表达 ,这两种作用可能部分是通过抑制甲羟戊酸 (MVA)的合成这个共同的机制所引起。
作者 魏丹 任江华 曹茂银
机构地区 武汉大学中南医院心内科
出处 《数理医药学杂志》 2004年第2期124-125,共2页 Journal of Mathematical Medicine
关键词 阿托伐他汀 动脉粥样硬化 兔 肿瘤坏死因子-Α 增殖细胞核抗原 药物治疗
分类号 R543.5 [医药卫生—心血管疾病] R972.6 [医药卫生—药品]
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参考文献17

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二级参考文献7

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数理医药学杂志
2004年 第2期

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