米非司酮对依沙吖啶中期妊娠引产影响的临床研究

A Clinical Study on Efficacy of Mifepristone for Induced Abortion Using Ethacridine at Intermediate Pregnancy.

目的:探讨术前用米非司酮,对依沙吖啶中期妊娠引产的临床效果影响,以减少引产并发症。方法:将231例要求中期妊娠引产的健康妇女分为3组,其中对照组67例,未用米非司酮;顿服组76例,口服米非司酮200mg,当日行依沙吖啶引产术;分服组88例,口服米非司酮10mg,qd×2d,第3天行依沙吖啶引产术。结果:米非司酮对宫颈的质地、颈管长度和宫口位置有明显的作用,对宫颈有软化和扩张的作用;米非司酮分服组平均引流时间为37.62±14.14h,与顿服组和对照组比较,有显著性差异(P<0.001);不论分服或顿服组,胎盘粘连的发生率(4.5％、3.9％)明显低于对照组(22.4％),同时产后刮出组织物的量也低于对照组。结论:米非司酮作为依沙吖啶中期妊娠引产的术前用药,能明显提高引产的有效性,减少引产并发症发生。

Objective: To investigate the clinic efficacy of Mifepristone for induced abortion using ethacridine at the second trimester pregnancy to reduce complications. Methods: 231 women in good health who asked for induced abortion at the second trimester pregnancy were divided into three groups. 67 cases did not took Mifepristone as control group. 76 cases took Mifepristone 200mg once before induced abortion as group A. 88 cases took Mifepristone 100mg qd×2d, followed by the induced abortion as group B. Results: Mifepris-tone is an effective drug for cervical ripening and softening. The time of induced abortion in group B was 37. 62±14. 14h which was significantly shorter than ones in the control group and group A( P <0.001). The incidence of placenta adherence (4. 5%、3. 9% ) and the amount of tissue scratched out from the uterus were significantly lower in group A and group B than ones (22. 4% ) in the control group. Conclusion: Mifepris-tone can improve efficacy of induced abortion which use Ethacridine at the second trimester pregnancy andreduce complications.