建立疟疾近期复发动物模型的研究 Ⅰ.食蟹猴疟原虫红外期裂殖体发育成熟的非同步性

STUDIES ON THE ESTABLISHMANT OF MALARIAL ANIMAL MODEL OF SHORT-TERM RELAPSE I. ASYNCHRONOUS GROWTH OF EXOERYTHSOCYTIC SCHIZONTS OF PLASMODIUM CYNOMOLGI

用引自越南的食蟹猴疟原虫子孢子感染恒河猴,第8d出现原虫血症,原虫密度为17/100白细胞,隔22h后,从肝活体组织中可检查到大量红外期裂殖体,其平均密度为3.74±0.66个/mm^3肝组织,它们绝大多数尚未发育至完全成熟,其分化程度参差不齐,平均直径为34.23±7.28μm,有的甚至近似于发育至第6d的红外期裂殖体,平均直径仅为15.75±2.47μm。结果说明红外期裂殖体发育成熟并非同步。

A monkey was infected with sporozoites of Plasmodium cynomolgi from Vietnam.Parasite emia was detected on the 8th day with a starting density of 17/100 white blood cells.22 hours after that time,many EE schizonts appeared with an average density of 3.74±0.66 per mm3 hepatic tissue in liver biopsy specimens from the monkey.Most of the EE schizonts were immature and grew at an uneven rate,having an average diameter of 34.22±7.28μm but some of them even remained 15.75±2.47μm in diameter similar to the EE.schizonts on the 6th day.The results showed that the EE schizonts of Plasmodium cynomolgi were asynchronous in growth.The authors suggest that the release of merozoites from liver might be a successive process for many times,and not to be completed at a time.