伊维菌素驱除肠道线虫的临床观察

CLINICAL OBSERVATION ON EFFICACY OF IVERMECTIN IN THE TREATMENT OF INTESTINAL NEMATODE INFECTIONS

将166例肠道线虫感染者分成3组,其中2组口服不同剂量的伊维菌素,另1组口服噻嘧啶为对照。结果:顿服伊维菌素0.1mg/kg组55例,蛔虫、钩虫和鞭虫的虫卵阴转率分别为100％,3.8％和50％;顿服伊维菌素0.2mg/kg组54例,蛔虫、钩虫和鞭虫卵的阴转率分别为95.5％、11.8％和76.5％;对照组顿服噻嘧啶10mg/kg组57例,蛔虫、钩虫和鞭虫卵阴转率分别为95.5％,29.6％和31.6％。3个组的副作用均轻微短暂。

A total of 166 cases were divided into 3 groups: group A comprised 55,group B 54 and group C 57 cases.Group A received ivermectin 0.1mg/kg orally at a single dore,the cure rates were 100%,3.8% and 50% for ascaris,hookworm and trichuris,infecfions respectively: group B received ivermectin 0.2mg/kg orally at a single dose,the corresponding cure rates were 95.5%,11.8% and 76.5% respectively; group C received pyrantel pamoate 10mg/kg orally at a single dose,the corresponding cure rates were 95.5%,29.6% and 31.6% respectively.Although the cure rates were very low for hookworm infection in both group A and B,however,a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm.Side effects were mild and transient in all groups.