论农药的宏观毒理学

On The Macro-toxicology of Pesticides

农药一旦喷撒到目标物上,即开始了向有害生物作用靶位转移的漫长历程。作者建议把此历程区分为两个范畴:进入有害生物体内以后的体内剂量转移是传统的生理毒理学研究领域,属于'微观毒理学'范畴;之前发生在生物体外的剂量转移历程尚未被作为毒理学问题研究,但许多边缘科学的大量科学事实和现象说明它们实际上属于毒理学问题,应属于'宏观毒理学'范畴。文章对农药宏观毒理学现象的7个方面进行了毒理学本质的分析和综述,并指出,对农药宏观毒理学的研究将大幅度提高农药的使用技术水平,大幅度降低农药用量,并将促进农药剂型和高性能助剂乃至新型合理化农药的研究开发。

Once a pesticide is applied onto the biological target (crop or pest), a long process of dose transfer will then be initiated until the terminal target site in the pest body is reached. As a quite long process, it is suggested by the author that it should be categorized into two different areas, the 'micro-toxicology' and the 'macro-toxicology'. The former conventionally deals with the physiological and biochemical change of (pesticides happened )within the organisms. But the dose transfer carried on outside the pest body has never been considered a toxicological process, although many scientific phenomena and facts revealed so far in different literatures have shown that they should be. The paper gave a brief commentary review upon those phenomena and( scientific facts )in 7 different areas from the macro-toxicological point of view. The author belief, to be a new science area of multi-disciplinary nature, 'macro-toxicology of pesticides' will (undoubtedly) promote the progress of pesticide application technology, the improvement of (pesticide) formulation, the development of (novel surfactants), and even the rational design of novel pesticides.