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P53、Fas、Bcl-2基因在尖锐湿疣和宫颈癌组织中的表达 被引量：3

Expression of P53,Fas and Bcl-2 in condyloma acuminatum and cervical cancer
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摘要 目的 :探讨P5 3、Fas、Bcl 2基因蛋白表达与尖锐湿疣和宫颈癌发病的关系。方法 :采用标准免疫组化技术 ,分别检测 2 4例尖锐湿疣、4 6例宫颈癌、2 2例宫颈糜烂和 2 8例正常宫颈组织P5 3、Fas和Bcl 2基因产物。结果 :三种基因蛋白在尖锐湿疣组和宫颈癌组的表达程度和表达率均显著高于宫颈糜烂组和正常对照组 (P <0 .0 0 1)。尖锐湿疣组和宫颈癌组之间在P5 3的表达程度上差异有显著性 (P <0 .0 5 )。结论 :P5 3、Fas、Bcl 2基因表达与尖锐湿疣和宫颈癌的发病均有密切关系。 Objective:To explore the pathogenetic relationship between expressions of P53, Fas and Bcl-2 associated with condyloma acuminatum(CA) and cervical cancer.Methods:The expressions of P53,Fas and Bcl-2 were detected using immuohistochemical technique in 24 specimens of CA,46 specimens of cervical cancer,22 specimens of cervicitis and 28 specimens of normal cervical tissue.Results:The expressive degree and expressive rate of p53,Fas and Bcl-2 in CA and cervical cancer were significantly higher than that in cervicitis and normal cervical tissue(p<0.001). The expressive degree of p53 was significantly difference between CA and cervical cancer(P<0.05).Conclusion:The expressions of p53,Fas and Bcl-2 were significantly correlated with the occurrences of both condyloma acuminatum and cervical cancer.
作者 夏克栋 林巧爱 董海艳 张丽芳 胡芸 董缪武
机构地区 温州医学院微生物学免疫学教研室 温州医学院病理学教研室
出处 《温州医学院学报》 CAS 2004年第2期82-84,共3页 Journal of Wenzhou Medical College
基金 温州市科技局科研基金资助项目 (S2 0 0 1A3 0 )
关键词 尖锐湿疣 宫颈癌 P53 FAS BCL-2 condyloma acuminatum cervical cancer P53 Fas Bcl-2
分类号 R752.5 [医药卫生—皮肤病学与性病学]
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参考文献7

  • 1Sheets EE, Yeh J. The role of apoptosis in gynaecological malignancies[J]. Ann Med, 1997,29(2) : 121 - 126.
  • 2Tjalma WA, Weyler JJ, Bogers JJ, et al. The importance of biological factors (bcl-2,bax,p53,PCNA,MI,HPV and angiogenesis) in invasive cervical cancer[J]. Eur J Obstet Gynecol Reprod Biol.2001,97(2):223 - 230.
  • 3Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV [ J]. Oncogene , 1999, 18 (53) : 7690 -7700.
  • 4Rapp L, Chen JJ. The papillomavirus E6 proteins[J]. Biochim Biophys Acta, 1998,1378(1 ) : F1 - 19.
  • 5Ferenczy A. Franco E. Persistent human papillomavirus infection and cervical neoplasia[J]. Lancet Oncol, 2002,3 (1) : 11 - 16.
  • 6Rouquet N. Allemand I, Molina T, et al. Fas-dependent apoptosis is impaired by SV40 T-antigen in transgenic liver[J]. Oncogene, 1995, 11(6) : 1061 - 1067.
  • 7姚嘉斐,武昕,生秀杰,李悦,王彤.细胞凋亡调节与宫颈癌发生[J].中国肿瘤临床,2002,29(1):49-52. 被引量：12

二级参考文献16

  • 1[1]Kerr JF, Wyllie AH and Gurrie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 1972, 26:239～257
  • 2[5]Gavrieli Y, Sherman Y and Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol, 1992, 119:493～501
  • 3[6]Raff MC. Social controls on cell survival and cell death. Nature, 1992, 356:397～400
  • 4[7]Yin C, Knudson CM, Korsmeyer SJ, et al. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature, 1997,385:637～640
  • 5[8]Mcdonnell TJ, Beham A, Sarkiss M, et al. Importance of the Bcl-2 family in cell death regulation. Experientia, 1996, 52:1008～1017
  • 6[9]Diller L, Kassel J, Nelson CE, et al. p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol, 1990,
  • 7[10]:5772～578110.Rowan S, and Fisher DE. Mechanisms of apoptotic cell death.Leukemia, 1997, 11:457～465
  • 8[11]Miyashita T, and Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 1995,80:293～299
  • 9[12]Mougin C, Humbey O, and Gay C, et al. Human papillomaviruses, ce 1l cycle and cervical cancer. J Gynecol Obstet Biol Reprod (Paris), 2000, 29(1): 13～20
  • 10[13]Thomas M, Pim D, and Banks L. The role of the E6-p53 interaction in the molectular pathogenesis of HPV. Oncogene,1999, 18(53): 7690～7700

共引文献11

同被引文献28

  • 1张景政,徐洁芳,唐书谦,叶庆佾,刘荣卿.尖锐湿疣患者郎格罕细胞观察[J].中国皮肤性病学杂志,1994,8(2):75-76. 被引量：3
  • 2李政霄,彭振辉,纪泛扑,袁景奕,潘敏,刘艳,王琼.上皮钙粘素和β-连环蛋白在皮肤Bowen病、鳞癌中的表达[J].南方医科大学学报,2006,26(8):1245-1247. 被引量：2
  • 3Drijkoningen M,De Wikf-Peeters C,Degref H et al.Epidermal Langerhans cells,dermal dendritic cells,and keratinocytes in viral lesions of skin and mucous membranes:A immunohistochemical study[J].Arch Dermatol Res,1988;280:220.
  • 4刘贞富.尖锐湿疣[M].修订版.武汉:湖北科学技术出版社,2004.8-82.
  • 5Byars RW,Poola GV,Barber WH.Anal carcinoma arising from condyloma acuminata[J].Am Surg,2001,67(5):469-472.
  • 6Tang WW,Stelter AA, French S,et al. Loss of cell-adhesion mole-cule complexes in solid pseudopapillary tumor of pancreas [ J ]. ModPathol,2007,324(1) :106 -119.
  • 7Anastasiadis PZ. P120 - ctn : A nexus for contextual signaling viaRho GTPases[ J]. Biochim Biophys Acta,2007 ,1773 (1) :34 -46.
  • 8Macpherson IR, Hooper S, Serrels A, et al. P120 - calenin is re-quired for the collective invasion of squamous cell carcinoma cellsvia a phosphorylation-independent mechanism [ J ]. Oncogene,2007,26(36) :135 - 142.
  • 9Yanagisawa M , Anastasiadis PZ. pi20 catenin is essential for mesen-ehymal cadherin-mediated regulation of cell motility and invasiveness[J]. J Cell Biol,2006,174(7) :1087 - 1096.
  • 10Tong GX, Chiriboga L, Hamele-Bena D, et al. Expression of PAX2 in papillary serous carcinoma of the ovary:immunohistochemical evidence of fallopian tube or secondary Mullerian system origin?[J]. Mod Pathol, 2007, 20(8):856-863.

引证文献3

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温州医学院学报
2004年 第2期

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