取代酚类极性有机物C_(18)膜/水分配行为的研究

Investigation of C_(18) Membrane/Water Partition Behavior for Polar Substituted Phenols

采用C18膜模拟生物体及高效液相色谱分析方法,探讨了极性有机化合物取代酚在C18膜与水相之间的分配规律,研究了pH和盐度对分配的影响,测定了取代酚的C18膜/水分配系数KSD。结果表明,取代酚达到分配平衡的时间很短,其C18膜/水分配系数不会因分配时间的延长而增大;随着取代酚的正辛醇/水分配系数的增大,化合物从水中向C18膜转化的比例逐渐增加,其相应的C18膜/水分配系数也随之增加;盐度的增加对极性化合物C18膜/水分配系数的大小没有显著的影响;pH的增大将降低化合物的分配系数。通过C18膜/水分配规律的研究,可以推测生物体或环境介质对取代酚类化合物的积累程度,由此可以较直观地评价该类化合物的环境持久性,以及因脂溶性所产生的生物基线毒性。为取代酚类化合物的生态风险评价和管理提供科学依据。

Partitioning factors between C18 solid phase extraction membrane and water for several substituted phenols are investigated in the present study. The C18 membrane/water partition coefficient is also determined. The results showed that with the increase of KOW values, the partition equilibrium time did not increase significantly. The equilibrium time was approximately one hour. We also found that the KSD values did not correlate with the concentrations of the salt in water. The partitioning process was affected by pH value, especially at pH 7. There was a good correlation between KSD and KOW. It may be concluded that the C18 solid phase material is useful in evaluating the polar organic compounds and predicting the baseline their toxicity.