摘要
TGF-b诱导早期基因(TGF-b-inducibleearlygene,TIEG)产物为Sp1样转录因子家族成员,其中TIEG1和TIEG2组成TIEG亚家族。TIEG1的稳定性与泛素-蛋白酶体路径有关。TIEG1C端保守的3锌指结构及N端的转录抑制区对于该蛋白功能的正常发挥十分重要。TIEG作为TGF-b诱导的立即早期转录基因,引起细胞形态发生改变,抑制细胞增殖并诱导凋亡。TIEG1在TGF-b-Smads信号通路中通过Smads成员发挥调节作用,其中与Smad7形成的负反馈环对该信号转导路径尤为重要。
TGF-b-inducible early gene(TIEG) is a member of the Sp1-like transcription factor family, TIEG1 andTIEG2 belong to a same subfamily. The stability of TIEG1 is associated with ubiqiutin-proteasomal pathways.The 3 zinc-finger motif in C-terminal and the transcriptional repression domain in N-terminal of TIEG1 areimportant to keep its normal function. As the immediate early gene induced by TGF-b, TIEG altered the cellmorphogenesis, inhibited cell proliferation and induced cell apoptosis. TIEG1 plays its role through the Smads,and the feedback formed by Smad7 and TIEG1 is very important in the TGF-b-Smads signaling pathways.
出处
《生命科学》
CSCD
2004年第2期84-89,共6页
Chinese Bulletin of Life Sciences