被动活动对小鼠失神经支配肌肉萎缩的影响

The effect of passive movement on denervated muscular atrophy in mice

将45只雌性小鼠随机平均分为3组,切断其两侧坐骨神经和股神经,术后第一天各组小鼠的右后肢作被动活动每日2回。第一组每回300次,第二组每回150次,第三组每回75次。实验结果提示,被动活动有减慢失神经支配肌萎缩的作用,并随活动次数增加肌萎缩减慢效果更明显。故临床治疗周围神经损伤中可应用被动活动,神经修复术后宜及早活动可能的关节。

The effect of passive movement on denervated muscular atrophy in mice/Chen De-song,et al//Chinese Journal of Rehabilitation Medicine, 1992, 7(5):215～216 Both-side sciatic nerves and femoral nerves of forty-five female mice were severed. The animal were diveded randomly into three groups (15 in each). Beginning from the first postoperative day, passive movement on the right limbs were performed twice a day, each one 300 times in the first group, 150 times in the second group, and 75 times in the third group. The experimental results suggested that the passive movement could slow down theatrophic rate of the denervated muscle, and the effect became more apparent with increasing of times of passive movement. It showed that in clinic, the passive movement could be used on those joints as early as possible after peripheral nerve injury and nerve repairing for the purpose of slowing down the atrophic rate of the denervated muscle. Authór's address: Microsurgery Research Unit, Huashan Hospital, Shanghai Medical University