强直性脊椎炎患者嗜中性粒细胞碱性磷酸酶活性与血清锌、铜的关系

A study of the relationship between the activity of NAP and the serous zinc in patients with ankylosing spondylitis

选取活动期强直性脊椎炎患者58例,经检测发现其嗜中性粒细胞碱性磷酸酶(NAP)活性下降,血清锌水平降低,同时发现白细胞内的中毒颗粒的出现率升高。与由100名大学生组成的正常对照组相比,上述变化有统计学意义。结果提示:强直性脊椎炎患者可能存在着抗菌及NAP活性方面的免疫功能缺陷;而补锌可能会提高NAP的活性。

In 58 cases of the ankylosing spondylitis (AS), we found that the activity of the neutrophil alkline phosphatase (NAP) decreased, with the lack of serous zinc and the increase of toxic granulus in leukocyte. Comparing with 100 cases of normal control group, these changes had the significant difference. The results showed that in AS patients there might be deficient in immunity function to bacteria and NAP. The supply of zinc could increase the activity of NAP.