摘要
本文用一次注射完全福氏佐剂——抗原乳剂加百日咳疫苗的方法在Wistar大鼠诱发了EAE,发病率在95％以上。一定剂量的高等真菌茯苓的提取物——茯苓素对EAE的诱发有抑制作用。茯苓素与环磷酰胺同时作用,对EAE的抑制有协同作用。
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease modelin animals primarily caused by cell-mediated injury. With guinea pig spinal cord homogenate ia complete Freund adjuvant and Bordetella pertussis vaccine, we succeeded in the induction of EAE in Wistar rats, confirmed that pertussis vaccine augmented EAE response, and demonstrated that two administrations of antigen-CFA emulsion at one week interval suppressed EAE development. When treated with Poriatin (po) or cyclophosphamide (ip) the incidence of the disease was lowered, and when given simultaneously a synergic effect was observed on EAE suppression.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1992年第1期38-41,共4页
Chinese Journal of Antibiotics
