摘要
茯苓素体外可结合到大鼠肾胞浆膜醛固酮受体上,体内可拮抗醛固酮活性,提高尿中Na^+/K^+比值,具有剂量依赖关系。它不影响大鼠血浆醛固酮和血管紧张素Ⅱ的水平。实验表明它可能是一种醛固酮受体拮杭剂。
Poriatin can bind to renal cytopiasmic aldosterone receptors in vitro and have an anti-aldosterone activity and enhances urinary Na+/K+ ratio with dose-dependence in rats. It did not affect the aldosteroae and angiotensinⅡ concentrations in rat plasma. These suggest that poriatin is an aldosterone antagonist.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1992年第1期34-37,共4页
Chinese Journal of Antibiotics
关键词
茯苓素
醛固酮
醛固酮拮抗剂
Poriatin: Aldosterone
Aldosterone antagonist
Aldosterone receptor
Na+/K+ ratio
